Activation of Nuclear Factor-kappaB in the Atherosclerotic Human Coronary Artery / 대한해부학회지
Korean Journal of Anatomy
;
: 111-118, 2006.
Article
in Korean
| WPRIM
| ID: wpr-656237
ABSTRACT
Paraffin sections of atherosclerotic vessels were classified into initial lesion, preatheroma and complicated severe lesion by classification method from American Heart Association. Activation of NF-kappaB was hardly detectable in the initial atherosclerotic lesion. In the preatheroma, activated NF-kappaB was enhanced in the neointimal smooth muscle cells and macrophages in the lipid core. In contrast, activated NF-kappaB increased markedly in the neointimal and medial smooth muscle cells in the severe atherosclerotic vessel wall. However, in the severe lesion, NF-kappaB activation was diminished in the macrophages of lipid core. Our findings show that NF-kappaB was activated in the smooth muscle cells with the progression of atherosclerosis in the human coronary artery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraffin
/
NF-kappa B
/
Classification
/
Coronary Vessels
/
Myocytes, Smooth Muscle
/
Atherosclerosis
/
American Heart Association
/
Macrophages
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anatomy
Year:
2006
Type:
Article
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