Tissue-Engineered Tracheal Regeneration: Current Status / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 153-157, 2017.
Article
in Korean
| WPRIM
| ID: wpr-656834
ABSTRACT
Tracheal regeneration is very challenging clinical demand because the trachea is not a simple windpipe, but a multilayered, complex structure. The tissue-engineering technique is widely accepted as promising strategy in tracheal regeneration. For successful regeneration, a substitute for trachea should provide not only appropriate laterally rigidity and longitudinally flexibility for sustaining the luminal shape of the trachea, but also favorable environment for respiratory ciliated epithelium, smooth muscle and blood vessel cells to regenerate. To date, a variety of materials such as polyglycolic acid, poly (lactic-co-glycolic acid), polycarprolactone, nanocomposite polymers and many naturally-derived scaffolds have been investigated. With these investigations, several clinical attempt of tracheal replacement with artificial trachea have been tried, but clinical outcome has not been quite satisfying. This article reviews the regeneration of C-shaped cartilage, respiratory ciliated epithelium and neovascularization of artificial trachea, together with the difficulties, plausible options and future perspectives.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenobarbital
/
Polyglycolic Acid
/
Polymers
/
Regeneration
/
Stem Cells
/
Trachea
/
Blood Vessels
/
Cartilage
/
Pliability
/
Tissue Engineering
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2017
Type:
Article
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