Changes in the Mechanoreceptors of the Anterior Cruciate Ligament of Patients with Degenerative Arthritis / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
;
: 672-677, 2003.
Article
in Korean
| WPRIM
| ID: wpr-656878
ABSTRACT
PURPOSE:
To clarify the morphologic and quantitative changes of mechanoreceptors of the human ACL with degenerative arthritis. MATERIALS ANDMETHODS:
Eleven fresh specimens of anterior cruciate ligament (ACL) were obtained from patients with degenerative arthritis during TKA. As a control, two fresh specimens were taken from healthy men at the time of a traumatic above knee amputation. The whole ligaments were serially frozen and sectioned at a thickness of 40 mum. After immunohistochemical staining, the mechanoreceptors were observed under a light microscope. The ratios of sections showing mechanoreceptors were calculated. Statistical analyses were performed using the chi-square test.RESULTS:
In the two control specimens, nineteen mechanoreceptors were found, evenly distributed at the femoral and tibial ends. However, the average number of mechanoreceptors was 1.4 (total 15) in the arthritic ligaments (p<0.05), and these were located near the femoral side rather than the tibial end. The percentage of sections showing mechanorecptors was 8.3% in the arthritic group and 40.2% in the control group (p<0.05). All receptors were round or fusiform shaped Ruffini corpuscles; Pacinian corpuscles could not be found in either group. Nine of 15 mechanoreceptors in the arthritic groups were "necrotic" in shape.CONCLUSION:
Mechanoreceptors in arthritic ACL were significantly reduced in number and mainly necrotic in shape. Our findings suggest that the numerical and morphological changes of mechanoreceptors are closely related with reduced proprioception in degenerative arthritis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoarthritis
/
Pacinian Corpuscles
/
Proprioception
/
Anterior Cruciate Ligament
/
Amputation, Surgical
/
Knee
/
Ligaments
/
Mechanoreceptors
Limits:
Humans
/
Male
Language:
Korean
Journal:
The Journal of the Korean Orthopaedic Association
Year:
2003
Type:
Article
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