Relationship between serum levels of ADMA ,CRP and atherosclerosis ,cardiovascular events in patients with type H hypertension / 国际检验医学杂志

ABSTRACT

Objective To investigate the relationship between serum levels of ADMA ,CRP and atherosclerosis ,cardiovascular e-vents in patients with type H hypertension .Methods Totally 80 patients with type H hypertension from August 2012 to August 2015 in our hospital were selected ,80 cases of non H type essential hypertension patiens were recruited as control group ,enzyme linked immunosorbent assay (ELISA) was used to detect serum levels of ADMA and CRP ,and carotid atherosclerosis was evalua-ted by ultrasonography .All patients were followed up regularly to record the occurrence of cardiovascular events ,and to investigate the relationship between ADMA and CRP levels and atherosclerosis and cardiovascular events .Results The levels of ADMA ,CRP and the rate of atherosclerosis in patients with type H hypertension were higher than those in the control group ,the difference was statistically significant (P<0 .05) .There were 37 cases of atherosclerosis in patients with type H hypertension ,and the levels of ADMA and CRP in patients with atherosclerosis were higher than those in non atherosclerosis group ,and the difference was statis-tically significant (P<0 .05) .Logistic regression analysis indicated that mean arterial pressure and ADMA levels were independent risk factors for cardiovascular events in patients (P<0 .05) .Conclusion Serum levels of ADMA are closely related to atherosclero-sis ,and are independent risk factors for cardiovascular events in patients with type H hypertension .