Analysis of the influence of two kinds of anesthesia methods on immunological indexes in patients with primary liver cancer during perioperative period / 国际检验医学杂志

ABSTRACT

Objective To investigate the effects of two kinds of anesthesia methods on the immunological function of patients with primary liver cancer during perioperative period .Methods The clinical data of 86 cases of primary liver cancer from December 2010 to December 2015 were collected and divided into control group and study group ,43 cases in each group .The control group re-ceived sevoflurane inhalation anesthesia ,and the study group was given intravenous anesthesia with propofol ,the effects of different anesthesia methods on T lymphocyte subsets ,IL-2 ,IL-6 and TNF-α were compared .Results The levels of CD3+ ,CD4+ ,CD8+ , CD4+ /CD8+ ,IL-2 ,IL-6 and TNF-αin the two groups before anesthesia were not statistically significant (P>0 .05) ,there was no significant difference in CD3+ ,CD8+ and IL-2 between the two groups after anesthesia (P>0 .05) .Compared with T0(before anes-thasia) ,the two groups decreased significantly on CD4+ and CD4+ /CD8+ at the T1(end of anesthesia) segment(P<0 .05) ,but the control group returned to the pre anesthesia level in the T 2(24 h after surgery ) segment ,the indexes at the T1 and T2 segment in the study group were higher than those in the control group (P<0 .05) ,and the level of IL-6 at T1 and T2 segment were signifi-cantly higher than those at the T0 segment (P<0 .05) .Compared with T0 ,the control group increased gradually on TNF-α (P<0 .05) ,while the study group only increased at the T1 segment (P<0 .05) ,and the T2 segment was restored to the pre-anesthesia induction .Conclusion Propofol and sevoflurane could inhibit the immune function of primary hepatocellular carcinoma ,but the de-gree of inhibition of propofol is relatively light ,and with less stress response .