Research status of endoplasmic reticulum-autophagy pathway in drug resistance of tumor / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 590-593, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-657419
ABSTRACT
Autophagy plays a dual role in tumor therapy.A variety of chemotherapy drugs can induce tumor autophagy by activating endoplasmic reticulum stress,and hyperactive autophagy can cause tumor cell apoptosis and plays an anti-tumor effect.Autophagy has a protective effect on tumor cells,which can maintain the survival of tumor cells and reduce the sensitivity of chemotherapy drugs by reusing the degradation of the damaged organelles.Therefore,the promotion or inhibition of autophagy modulators combined with chemotherapy drugs will have the potential for development in tumor therapy.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2017
Type:
Article
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