Efficacy of nursing intervention combined with donepezil in the treatment of senile dementia / 中国生化药物杂志

ABSTRACT

Objective To investigate and analyze the efficacy of nursing intervention combined with donepezil in the treatment of senile dementia. Methods 100 patients with Alzheimer's disease from February 2015 to August 2016 in our hospital were randomly divided into the control group and the experimental group, with 50 cases in each group. The patients in control group were treated with donepezil hydrochloride, and the experimental group was given nursing intervention measures, reasonable nursing program, comfortable medical environment, targeted safety nursing and psychological nursing were given. The clinical efficacy of the two groups was compared. Results After treatment, the effective rate of the experimental group was 94.0%, which was significantly higher than that of the control group, and the effective rate was 76.0%, the differences were statistically significant(P<0.05). After treatment, the scores of MMSE and ADL in the experimental group were (22.30±3.12) and (62.33±11.45) significantly better than that of the control group, the differences were statistically significant(P<0.05). The incidence of adverse reactions in the two groups was 10% and 12%, respectively, and there was no statistical significance. Conclusion The clinical efficacy of nursing intervention combined with donepezil in the treatment of senile dementia is ideal, can significantly improve the cognitive ability of patients, and has high security.