Determination and pharmacokinetics of Glutathione Buccal Tablets tablet by HPLC / 中国生化药物杂志

ABSTRACT

Objective To explore the differences in the pharmacokinetics of Glutathione Buccal Tablets and tablets. Methods 20 volunteers received pharmacokinetic experiments, using single dose crossover parallel mode of administration, the HPLC method for the determination of plasma concentration time parameters to evaluate the pharmacokinetics. Results The difference was statistically significant the blood concentration of subjects after taking 0.25 to 5 h during the same time point of two forms of group, GSH tablet drug stability is better than that of GSH (P<0.05). GSH tablets into tablets Cloth (t1/2) 1.56 h, the half-life was significantly lower than that of GSH (P<0.05). GSH tablets tablets glutathione concentration peak time (tmax) of 1.75h was significantly higher than that of GSH (P<0.05) GSH tablets, tablets of glutathione concentration peak (Cmax) of 11.077, significantly higher than that of GSH tablets (P<0.05). Conclusion The peak plasma concentration of GSH tablets higher. Reach the peak concentration time and time longer, the pharmacokinetics of GSH tablets is better than that of GSH tablet, which has broad application prospect.