Prognostic value of serum CXCL12 and IL-33 levels in patients with acute ischemic stroke / 中国免疫学杂志

ABSTRACT

Objective:To explore the prognostic value of serum CXCL12 and IL-33 levels in patients with acute ischemic stroke. Methods:From December 2014 to June 2016,the patients with acute ischemic stroke in our hospital as the case group(122 cases) and healthy volunteer were recruited as normal group ( 59 cases ) . According to the mRS scores patients were divided into favorable outcomes group(86 cases) and unfavorable outcomes group(36 cases). On admission the serum CXCL12 and IL-33 levels of objects were measured by ELISA. Receiver operating characteristic curve( ROC) and AUV were used to evaluate the prognostic value serum CXCL12 and IL-33 in patients with acute ischemic stroke. The serum CXCL12 levels were significantly higher in the patients with acute ischemic stroke compared to the control group[8. 0 ng/ml(IQR,6. 7-8. 9) VS 3. 0 ng/ml(IQR,2. 3-3. 8),P<0. 001],and serum IL-33 levels were also significantly higher than those in the control group [ 65. 25 ng/L ( IQR,56. 05-71. 08 ) VS 35. 30 ng/L (IQR,26. 73-42. 55),P<0. 001]. The serum CXCL12 levels were significantly lower in patients with a favorable outcome group[7. 4 ng/ml(IQR,6. 3-8. 3)] compared with patients with an unfavorable outcome group[9. 3 ng/ml(IQR,8. 3-11. 1)],and IL-33 levels were also significantly lower than that of unfavorable outcomes group[66. 81 ng/L(IQR,61. 12-73. 29)VS 55. 38 ng/L(IQR,46. 75-64. 71),P<0. 001] . Pearson correlation analysis showed that serum CXCL12 and IL-33 levels were respectively positively and negatively correlated with mRS score(r=0. 524,P<0. 001;r=-0. 443,P<0. 001). The serum CXCL12 and IL-33 levels as an indicator for prognosis of functional outcome. The area under the curve was 0. 835,0. 784 respectively. The sensitivity was 77. 8%,83. 4%respectively and specificity was 73. 3%,66. 7% respectively. Conclusion:Serum CXCL12 and IL-33 levels can be used as markers for the prognosis of patients with acute ischemic stroke.