Rare Presentation of Richter's Transformation to Diffuse Large B Cell Lymphoma: a Case Report / 대한내과학회지
Korean Journal of Medicine
;
: 163-168, 2016.
Article
in Korean
| WPRIM
| ID: wpr-65764
ABSTRACT
Richter's syndrome refers to the development of aggressive lymphoma in a patient with chronic lymphocytic leukemia (CLL). It occurs in about 2% to 10% of patients with CLL. The most frequent manifestation of Richter's syndrome is diffuse large B cell lymphoma (DLBCL). Extranodal involvement is rare but can occur. The prognosis of Richter's syndrome is very poor. We herein report a case of a rare presentation of Richter's syndrome. A 42-year-old man diagnosed with CLL 2 years previously developed nodules on the bilateral thighs and buttocks. A positron emission tomography (PET)-CT scan revealed high fluorodeoxyglucose uptake in multiple lymph nodes, skeletal muscles, and the myocardium. An ultrasonography-guided biopsy confirmed Richter's syndrome from CLL to DLBCL. The patient was treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy. After six cycles of chemotherapy, we performed a PET-CT scan that revealed a complete response. However, 3 months later, the syndrome recurred. The patient was undergoing salvage chemotherapy at the time of this writing.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Thigh
/
Vincristine
/
Writing
/
Biopsy
/
Buttocks
/
Prednisone
/
Leukemia, Lymphocytic, Chronic, B-Cell
/
Doxorubicin
/
Lymphoma, B-Cell
Type of study:
Prognostic study
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2016
Type:
Article
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