CT and pathological analysis of primary pulmonary synovial sarcoma / 实用放射学杂志

ABSTRACT

Objective To explore the CT characteristics of primary pulmonary synovial sarcoma (PPSS)to improve the understanding of the disease.Methods The clinical,imaging and pathological data of 5 patients with PPSS confirmed by operation and pathology was analyzed retrospectively.4 patients underwent enhanced CT scan,and 1 patient underwent plain CT scan.STY-SSX fusion genes of 3 patients were detected by reverse transcriptase-polymerase chain reaction (RT-PCR).Results All the lesions were located in the upper lobe of the lung.Most lesions showed as round-like heterogeneous solid masses with clear edge,3 lesions showed heterogeneous enhancement,and 2 lesions showed circular enhancement with obviously enhanced parenchyma.1 lesion was with calcification,3 lesions were with ipsilateral pleural effusion,and mediastinal lymph nodes metastasis was seen in 1 case.The immunohistochemical results showed that the expressions of Vim,CD56,CD99,Bcl-2 and Ki-67 were positive.Only 1 case was EMA individually positive.SYT-SSX gene was detected in 3 cases.Conclusion The imaging findings of PPSS are relatively specific,the diagnosis mainly relies on pathological, immunohistochemical examination and SYT-SSX detection.