Genetic polymorphisms of RTN4 gene in Chinese Guangxi population / 中国病理生理杂志

ABSTRACT

AIM:To investigate the distribution characteristics of rs 2920891A/C and rs17046647A/G poly-morphisms of RTN4 gene in Guangxi population , and to compare the differences among different populations .METHODS:The genotypes of RTN4 gene at rs2920891A/C and rs17046647A/G in 323 healthy persons of Guangxi were performed by the technique of SNaPshot and DNA sequencing .The results were compared with the alleles and genotypes of other popula-tions (HapMap-CEU, HapMap-HCB, HapMap-JPT and HapMap-YRI in HapMap).RESULTS: In Guangxi population, 3 genotypes, AA, AC and CC, and 2 alleles, A and C, were found in rs2920891A/C.The allele frequencies between male and female showed significant differences (P<0.05).The genotype and allele frequencies compared with HapMap-JPT, HapMap-CEU and HapMap-YRI had differences with statistical significance ( P<0.05 ) .Three genotypes , AA, AG and GG, and 2 alleles, A and G, were found in rs17046647A/G.The genotype and allele frequencies between male and female showed no significant differences (P>0.05), but there were significant differences of the genotype and allele frequencies as compared with HapMap-JPT, HapMap-CEU and HapMap-YRI (P<0.01).CONCLUSION: The rs2920891A/C and rs17046647A/G polymorphisms of RTN4 gene in Chinese Guangxi population are different from those in other races .