Relationship between serum FABP4,FGF21,Nesfatin -1 and insulin resistance in patients with gestational diabetes mellitus / 中国基层医药

ABSTRACT

Objective To investigate the relationship between insulin resistance and FABP4,FGF21 and Nesfatin-1 in patients with gestational diabetes mellitus ( GDM) . Methods 60 patients with GDM were selected as the observation group,60 healthy pregnant women served as control group. The indicators of blood lipid,blood sugar, insulin resistance and the levels of FABP4, FGF21 and Nesfatin -1 were compared between the two groups. The correlation of FABP4,FGF21,Nesfatin -1 and insulin resistance was analyzed. Results The FABP4 [(27. 39 ± 3.58)μg/Lvs.(18.41±3.62)μg/L],FGF21[(193.29±17.31)ng/Lvs.(102.83±18.33)ng/L],Nesfatin-1 [(2. 49 ± 0. 61)μg/L vs. (1. 97 ± 0. 56)μg/L] levels of the observation group were significantly higher than those of the control group,the differences were statistically significant (t =13. 662,27. 728,4. 862,all P <0. 05). Pearson correlation analysis showed that FABP4,FGF21,Nesfatin-1 (r=0. 489,0. 368,0. 968,all P<0. 05) were positively associated with HOMAIR,and were negatively correlated with HOMA beta,ISI ( r= -0. 567,-0. 389,-0. 722,-0. 497,-0. 674,-0. 957,all P<0. 05). Conclusion There is obvious disorder of glucose and lipid metabolism and insulin resistance in patients with GDM. The serum levels of FABP4,FGF21 and Nesfatin-1 are significantly increased,and are related to insulin resistance.