Pharmacokinetics of tectorigenin in rabbit / 中成药
Chinese Traditional Patent Medicine
;
(12): 2014-2017, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-657976
ABSTRACT
AIM To develop a HPLC method for determining tectorigenin content in rabbit plasma for pharmacokinetics.METHODS As self crossover control,the rabbits,six Japanese giant ear rabbits were subject to a singledose intragastric administration of 60 mg/kg (tectorigenin 40 mg/kg) pueraria isoflavone.The free and enzymatic tectorigenin contents in plasma were measured by HPLC,and then pharmacokinetic parameters were calculated by PKsolver 2.0 pharmacokinetic program.RESULTS The AUC0-t,Tmax,Cmax after intragastric administration of pueraria isoflavone were (46.78 ±5.12) μg · min/mL,(5.39 ±0.54) min,(0.84 ±0.21) μg/mL for free tectorigenin,respectively;(485.48 ±23.53) μg · min/mL,(20.12 ±2.84) min,(2.95 ±0.67) μg/mL for total tectorigenin,respectively.CONCLUSION HPLC method is suitable for tectorigenin pharmacokinetic study.Tectorigenin is present mainly as glucuronide conjugates in plasma after intragastric administration pueraria isoflavone.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
2017
Type:
Article
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