Influence of intracoronary tirofiban application on coronary blood flow,endothelial function and in-flammatory factors in AMI patients / 心血管康复医学杂志

ABSTRACT

Objective:To explore influence of intracoronary tirofiban application during percutaneous coronary intervention (PCI)on coronary blood flow,endothelial function and inflammatory factor levels in patients with acute myocardial infarc-tion (AMI).Methods:A total of 90 AMI patients undergoing PCI in our hospital were selected.According to random num-ber table,patients were randomly and equally divided into routine PCI group and combined treatment group (received intra-coronary tirofiban treatment during PCI).Coronary blood flow,serum levels of soluble intercellular adhesion molecule-1 (sICAM-1),soluble vascular cell adhesion molecule-1 (sVCAM-1),von Willebrand factor (vWF),interleukin (IL)-6, IL-10 and IL-17 after PCI were compared between two groups.Results:After PCI,TIMI grade 3 rate in combined treat-ment group was significantly higher than that of routine PCI group (77.78% vs.57.78%),P =0.042. Compared with be-fore PCI,after PCI,there were significant rise in serum levels of sICAM-1,sVCAM-1,vWF and IL-10,significant reduc-tions in serum levels of IL-6 and IL-17 in two groups,P =0.001 all;compared with routine PCI group after PCI,there were significant reductions in serum levels of sICAM-1 [(28.1±4.7)μg/L vs.(22.9±3.4)μg/L],sVCAM-1 [(34.1 ±5.5)μg/L vs.(24.0±3.7)μg/L],vWF [(661.5±94.2)U/L vs.(497.0±85.8)U/L],IL-6 [(5.01±1.16)ng/L vs.(3.30±0.82)ng/L]and IL-17 [(19.74±4.96)ng/L vs.(15.98±3.20)ng/L],and significant rise in serum IL-10 level [(2.16±0.45)ng/L vs.(2.89±0.48)ng/L]in combined treatment group,P =0.001 all.Conclusion:Intra-coronary tirofiban application during PCI can further improve coronary blood flow,relieve inflammatory response and en-dothelial function injury in AMI patients,which is worth extending.