Relationship among serum A-FABP,chemokine CXCL12 and onset,severity of AIS in aged AIS pa-tients / 心血管康复医学杂志

ABSTRACT

Objective:To explore relationship among serum levels of adipocyte fatty acid binding protein (A-FABP), chemokine CXCL12 and acute ischemic stroke (AIS).Methods:A total of 92 aged AIS patients treated in our hospi-tal were selected as AIS group,another 83 healthy subjects undergoing physical examination in our hospital were en-rolled as healthy control group.Serum levels of A-FABP and chemokine CXCL12 were measured and compared be-tween two groups;United states national institutes of health stroke score (NIHSS)was used to assess neurological function deficit degree;Glasgow coma scale (GCS)was used to judge their consciousness.AIS patients were fol-lowed up for three months,then modified Rankin rating score (mRS)was used to assess their prognosis.Results:Compared with healthy control group,there were significant rise in serum levels of A-FABP [(20.92±2.63)μg/L vs.(35.63±5.72)μg/L]and chemokine CXCL12 [(4.25 ±0.61 )ng/ml vs.(24.31 ±3.46)ng/ml]in AIS group,P =0.001 both.Compared with small-medium size infraction group,NIHSS score≤15 scores group,GCS score≤8 scores group and good prognosis group,the levels of FABP [(32.89±5.34)μg/L,(31.72±4.15)μg/L, (30.68±4.21)μg/L,(32.17±3.72)μg/L vs.(38.24±5.86 )μg/L,(39.58±4.28)μg/L,(40.97±4.24)μg/L,(38.92±4.35)μg/L;chemokine CXCL12 [(21.38±3.18)ng /ml, (21.03 ±2.45)ng/ml,(20.78±2.42) ng/ml,(21.54±2.67)ng/ml vs.(28.26±3.37)ng/ml,(27.18±2.94)ng/ml,(27.51±2.89)ng/ml,(27.23±3.15)ng/ml]significantly rose (P <0.01 all)in large size infarction group,NIHSS score > 15 scores group,GCS score>8 scores group and poor prognosis group.Conclusion:Serum levels of A-FABP and chemokine CXCL12 are closely related to occurrence and severity of AIS,which can be used as important indexes for early diagnosis,disease monitor and prognosis assessment in AIS patients.