Expressions of Clusterin and E-cadherin in cervical squamous carcinoma and their correlation / 西安交通大学学报(医学版)

ABSTRACT

Objective To explore the expressions of clusterin and E-cadherin in cervical squamous tissues and their correlation.Methods Immunohistochemical technique was used to measure the expressions of clusterin and E-cadherin in 18 normal cervical tissues,32 cervical intraepithelial neoplasia (CIN)tissues and 40 cervical squamous carcinoma (CSC)tissues.Results There were on significant differences in baseline characteristics among the three groups based on standardized differences.The expressions of clusterin in CSC,CIN2 and CIN3 tissues were significantly higher than those in normal cervical tissues (P <0.05 ).The expression of clusterin was significantly lower in grade Ⅰ than in grade Ⅲ (P <0.01)and was connected with clinical stage (P <0.05 )instead of lymph node metastasis and cancer stromal invasion depth (P > 0.05 ).The expressions of E-cadherin in tissues of CSC, CIN2 and CIN3 were significantly lower than those in normal cervical tissues (P <0.05).E-cadherin expression was both significantly higher in grade Ⅰ and grade Ⅱ than in grade Ⅲ (P <0.05),and was associated with lymph node metastasis (P < 0.05 )rather than clinical stage and cancer stromal invasion depth (P > 0.05 ).A negative correlation was found between the expressions of clusterin and E-cadherin in CSC (r = - 0.339,P < 0.05 ). Conclusion The significantly different expressions of clusterin and E-cadherin may be related to the development of CSC,suggesting that the two may be used as potential markers for early diagnosis of CSC.