Preventive Use of Proton Pump Inhibitors in Critical Patients / 中国药师

ABSTRACT

Proton pump inhibitors ( PPI) have been widely used in clinics because of strong and lasting inhibiting effect on gastric acid secretion. Because of the higher incidence of stress ulcer and more drug combination used in critical patients, the use of PPI is more important. It has been proved that PPI used in critical patients may increase the incidence of serious adverse events, such as clos-tridium difficile associated diarrhea and pneumonia, so the rational use of PPI is more important in critical patients, especially for the preventive use. The preventive use of PPI including the prevention of drug-related upper gastrointestinal damage and stress ulcer in crit-ical patients was reviewed in the paper in order to provide reference for the rational drug use.