Effect of Bifid Triple Viable Capsules Adjuvant Tharapy and Influence on Inflammation Cytokine in Type 2 Diabetes Mellitus / 中国药师

ABSTRACT

Objective:To investigate the clinical effect of probiotics adjuvant therapy and influence on inflammation in the patients with type 2 diabetes mellitus (T2DM). Methods:Totally 102 patients with T2DM were divided into probiotics group (n=53) and the control group (n=49)according to the odd-even admission number. The control group received metformin tablets of 0. 5g,po,tid,pro-bioties group received bifid triple viable capsules of 0. 42g,po,tid additionally, and the treatment course was 8 weeks. Before and after the treatment, the levels of fructosamine(FMN), fasting bloodglucose(FBG),HbA1c,and the serum levels of TNF-αand adiponectin were determined, and the adverse reactions were recorded. Results:After the treatment, the levels of FMN, FBG, HbA1c and TNF-αof the two groups were significantly decreased than before, and adiponectin was significantly increased than before (P<0. 05); com-pared with those of the control group, the indicators mentioned above were improved more greatly in probiotic group (P<0. 05). There were no obvious adverse reactions appeared in both groups. Conclusion:Probiotics is beneficial to glycemic control, and the mecha-nism is related to reducing inflammation.