Cholesterol Lowering Effects of Low-dose Statins in Korean Patients
Journal of Lipid and Atherosclerosis
;
: 21-28, 2014.
Article
in Korean
| WPRIM
| ID: wpr-65823
ABSTRACT
OBJECTIVE:
The aim of this study is to compare cholesterol lowering effects of low dose 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) in Korean patients.METHODS:
A total of 909 consecutive patients were enrolled prospectively according to the criteria of National Cholesterol Education Program guidelines. Lipid profiles were obtained before and 2 months after statin therapy.RESULTS:
Atorvastatin 10 mg (n=260), lovastatin 20 mg (n=145), pitavastatin 2 mg (n=80), pravastatin 20 mg (n=28), rosuvastatin 5 mg (n=145), and simvastatin 20 mg (n=208) reduced low density lipoprotein (LDL) cholesterol by -41.8+/-11.0%, -33.8+/-12.8%, -39.3+/-10.8%, -31.5+/-8.9%, -48.8+/-12.3%, and -42.8+/-13.5%, respectively. LDL cholesterol less than 130 mg/dL was achieved in 90.3%, 76.9%, 88.5%, 85.2%, 97.2%, and 94.2%, respectively. The reduction of LDL cholesterol by 30% or more was obtained in 84.4%, 60.7%, 81.6%, 63.0%, 93.0%, and 83.5%, respectively. LDL cholesterol less than 70 mg/dL or the reduction by 50% or more was observed in a small portion of patients and was variable according to the different types of statins.CONCLUSION:
A low dose statin was enough to manage dyslipidemia in most Korean patients with low to moderate risks and was even effective in a subpopulation of high risk patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxidoreductases
/
Lovastatin
/
Cholesterol
/
Prospective Studies
/
Pravastatin
/
Coenzyme A
/
Hydroxymethylglutaryl-CoA Reductase Inhibitors
/
Simvastatin
/
Education
/
Dyslipidemias
Type of study:
Practice guideline
/
Observational study
Limits:
Humans
Language:
Korean
Journal:
Journal of Lipid and Atherosclerosis
Year:
2014
Type:
Article
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