The evaluation value analysis of serum CEA and CA15-3 levels in breast cancer on chemotherapy curative prognosis evaluation / 国际检验医学杂志

ABSTRACT

Objective To investigate the value of serum CEA and CA15-3 in the evaluation of breast cancer chemotherapy and prognosis.Methods 63 breast cancer patients were retrospectively analyzed from May 2011 to June 2012 in our Hospitals as breast cancer group,according to the situation of survival would be divided into survival group(n=42) and death group(n=21) and select indicators for outpatient medical normal crowd 63 cases as normal group.Serum levels of CEA and CA15-3 were measured by fluorescence immunoassay for 4 years.The prognosis of all patients was analyzed statistically.Results Serum level of CEA and CA15-3 in Ⅳ period breast cancer patients was obviously higher than Ⅲ period,the difference was statistically significant(P＜ 0.05).Chemotherapy efficient of CEA,CA15-3,CEA and CA15-3 express in negative group were obviously higher than positive group,the difference was statistically significant(P＜0.05).All patients were followed up for 1 to 4 years with an average follow-up time of 3.63 years and 42 patients survived for more than 4 years.CEA positive group patients of 4 years survival rate(55.26％) was obviously lower than negative group(84.00 ％),the difference was statistically significant(P＜0.05).CA15-3positive group patients of 5 years survival rate(52.78％) was obviously lower than negative group(85.19 ％),the difference was statistically significant(P＜ 0.05).CEA and CA15-3 positive group patients of 5 years survival rate (52.38％) was obviously lower than negative group (95.24％),the difference was statistically significant (P ＜ 0.05).Before treatment the serum CEA and CA15-3 level Survival groups was lower than death group,the difference was statistically significant(P＜0.05).Conclusion Detection of serum CEA and CA15-3 levels in patients with breast cancer before chemotherapy can provide reference data for chemotherapy efficacy and prognosis evaluation.Detection of breast cancer patients with chemotherapy before serum CEA and CA15-3 levels can provide reference for chemotherapy curative effect and prognosis assessment data.