Detection of IgM antibodies in pathogens caused respiratory tract infections of children in Chengdu area / 国际检验医学杂志

ABSTRACT

Objective To understand the epidemiological characteristics of IgM antibodies against 9 kinds of respiratory patho gens of children in Chengdu area so as to provide evidence for clinically effective prevention and treatment.Methods The IgM antibodies of 9 pathogens in the serum were detected by using indirect immunofluorescence assay.The positive rate of IgM antibodies and its seasonal distribution were observed.Results Among 20 647 cases,there were total 5 623 positive cases of IgM antibodies against 9 kinds of respiratory pathogens and the positive rate was 27.23％;The positive rate of mycoplasma pneumoniae(MP) was highest,followed by influenza B virus (INFBV) and parainfluenza virus (PIV) with the detection rate of 15.95％,6.27％ and 4.35 ％,respectively.Positive rates of MP,INFBV and PIV of girls were higher than those of boys,and the difference was statistically significant(P＜0.05);The distribution differences of most pathogens infection were statistically significant in different age groups(P＜0.05);In addition,infection of most them displayed a seasonal distribution,and the difference were statistically significant(P＜0.05).Conclusion MP and INFBV are the main pathogens in respiratory tract infection of children in Chengdu area,and the infection rates of MP,INFBV and PIV among girls more higher than that among boys,and the incidence of the infections caused by the respiratory tract pathogens vary in the age and seasons.