Preparation and Determination of Release of Berberine Sustained-release Tablets Containing Chitosan in Vitro / 医药导报

ABSTRACT

Objective To prepare berberine chitosan sustained-release tablets and to study the in vitro release characteristics. Methods The chitosan sustained-release tablets were prepared by chitosan as the skeleton material,and the drug release rate of berberine hydrochloride at different time was determined by high performance liquid chromatography. Results The in vitro cumulative release of berberine chitosan sustained-release tablets was increased with time.Furthermore,it can sustain for 24 h and the accumulative release was above 95%, the dissolution time of 63. 2% of the drug was 12. 63 h. Artificial gastric juice had the best performance on the dissolution of berberine,while rotations only influenced the dissolution at the beginning of drug release. Conclusion This method is convenient, accurate and reproducible.Berberine chitosan sustained-release tablets have further development and application value.