Clinical significance of preoperative serum level of mesothelin in colon cancer patients / 国际外科学杂志

ABSTRACT

Objective To investigate the different expression of preoperative serum mesothelin level in colon cancer patients.Methods One hundred and twenty five patients who were first diagnosed with colon cancer (a scase group) and 75 healthy subjects (a scontrol group) were enrolled in the Fourth People's Hospital of Yulin from Mar.2014 to Jun.2016.The serum levels of mesothelin both in the preoperative case group and control group were detected by enzyme linked immunosorbent assay.Diagnostic value of mesothelin in colon cancer was evaluated by receiver operating characteristic curve.The survival data of both goups were analyzed by Kaplan-Meier and Logrank test.Results Serum endothelin level in the control group was significantly lower than those in the case group [(0.91 ± 0.80) pg/ml and (7.63 ± 3.25) pg/ml,repectively,t =17.57,P ＜ 0.001].There were significant differences in the serum level of endothelin varied significantly in case group with tumor size,TNM stage,invasion,lymph node metastasis and distal metastasis (P ＜ 0.05).The best preoperative diagnostic value for serum levels of colon cancer was 2.36 pg/ml,and the best preoperative diagnostic value was 8.62 pg/ml for predicting the progression of colon cancer.One hundred and twenty-five cases of colon cancer were divided into low serum mesothelin group (n =56,the level of mesothelin ≤ 8.62 pg/ml) and high serum mesothelin group (n =69,the level of mesothelin ＞ 8.62 pg/ml).The difference of survival between the two groups was statistically significant (t =36.01,P ＜ 0.001).Conclusion Serum mesothelin may serve as a potential biomarker for the diagnosis of colon cancer and its progression.