Roles of endoplasmic reticulum stress in early brain injury after subarachnoid hemorrhage / 国际脑血管病杂志

ABSTRACT

Spontaneous subarachnoid hemorrhage (SAH) is a common acute cerebrovascular disease with high morbidity and mortality in clinical practice.Recent studies have shown that early brain injury (EBI)would occur within 72 h after SAH,and is closely associated with the poor outcome in patients with SAH.There are many possible mechanisms resulting in EBI,such as inflammation,autophagy,apoptosis.These damage mechanisms are all associated with endoplasmic reticulum stress.This article reviews the roles of endoplasmic reticulum stress in EBI after SAH.