The expression and clinical significance of interleukin-18 and interleukin-33 in serum of patients with acute asthma attack / 中国医师进修杂志

ABSTRACT

Objective To analyze the relationship between serum levels of interleukin (IL)-33 , IL-18 and the level of immunoglobulin-E (IgE), eosinophils (EOS) in patients with acute asthma attack. Methods Eighty patients of acute asthma attack (observation group) and 80 cases of healthy physical examination (control group) were selected. The levels of IL-33 and IL-18 were determined by enzyme-linked immunosorbent assay (ELISA) method and compared between two groups. The levels of EOS and IgE were measured by automatic analyzer , and the relationship between serum levels of interleukin (IL)-33 and IL-18 and the level of immunoglobulin-E (IgE) and eosinophils (EOS) was analyzed in patients with acute asthma attack. Results The levels of IL-18 and IL-33 in observation group were (310.2 ± 152.6), (215.4 ± 87.5) ng/L, in control group were(204.2 ± 95.4), (138.7 ±48.3) ng/L, and there were significant differences (P < 0.05). The levels of IL-18 and IL-33 in observation group after treatment were (215.5 ± 98.2), (146.6 ± 54.9) ng/L, significantly lower than those before treatment (P<0.05). The levels of EOS and IgE had positive relation with the level of IgE and EOS (P < 0.05). Conclusions The levels of IL-18 and IL-33 in patients with acute asthma attack increase, and both of them significantly decrease after treatment. They are positively correlated with IgE and EOS.