Effects of lysine and gluconic acid zinc granules combined with cimetidine on serum creatine kinase isoenzyme, aspartate aminotransferase and interleukin-6 levels and prognosis in children with rotavirus enteritis / 中国医师进修杂志

ABSTRACT

Objective To investigate the effects of lysine and gluconic acid zinc granules combined with cimetidine on serum creatine kinase isoenzyme (CK-MB), aspartate aminotransferase (AST) and interleukin-6 (IL-6) levels and prognosis in children with rotavirus enteritis. Methods Eighty-one children with rotavirus enteritis were randomly divided into control group (40 patients) and observation group (41 patients).The patients in control group were treated with cimetidine, and those in the observation group were treated with cimetidine combined with lysine and gluconic acid zinc granules. Clinical treatment, dehydration correction time, diarrhea time, fever time and serum CK-MB, AST and IL-6 levels were observed and compared between two groups. The occurrence of toxic side effects and vitality, physiological function, mental status scores were statistically analyzed. Results The total effective rate in observation group was 95.12%(39/41), in control group was 75.00%(30/40), and there was significant difference (P < 0.05). The dehydration correction time, diarrhea time, fever time after treatment in observation group was less than that in control group (P<0.05). The serum CK-MB, AST and IL-6 levels after treatment in observation group were significantly lower than those in control group (P<0.01). There was no significant difference in the incidence of side effects between observation group 17.07%(7/41) and control group 10.00%(4/40) (P>0.05). The scores of physiological function, vitality and mental status scores in observation group were higher those in control group, and there were significant differences(P < 0.01). Conclusions The lysine and gluconic acid zinc granules combined with cimetidine in the treatment of rotavirus enteritis gets has a significant effect and high safety, which can alleviate the inflammatory reaction and improve the myocardial enzymes levels and the quality of life.