Study progress of cyclooxygenase 2/membrane associated prostaglandin E2 synthase1/prostaglandin E2 pathway in podocyte injury / 中华实用儿科临床杂志

ABSTRACT

Podocyte injury is one of the common pathological features of glomerular disease in children,and it is closely related to the development of nephropathy.Podocytopathies is the glomerular disease with abnormal structure or function in podocyte which present different pathological extent,and may progress into chronic kidney disease.Therefore,finding the effective treatment is the focus of clinical research.Recent reports have shown that cyclooxygenase 2 (COX-2) / membrane associated prostaglandin E2 synthase 1 (mPGES-1) / prostaglandin E2 (PGE2) pathway plays a critical role in podocyte injury.The inhibition of the above pathway could be a new method for the therapy of podocytopathies.This article reviews the research progress of COX-2/mPGES-1/PGE2 pathway in podocyte injury.