Animal models of dengue virus infection / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
; (12): 712-720, 2017.
Article
in Zh
| WPRIM
| ID: wpr-659137
Responsible library:
WPRO
ABSTRACT
Dengue virus ( DENV) threatens the lives of hundreds of millions of people every year. Animal model is an effective tool for virus pathogenesis research and vaccine evaluation. At present, the de-velopment of animal models of DENV infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. Animal models of dengue virus infection are mainly non-human pri-mate ( NHP) model and mouse model. NHPs have been used to study dengue infection and candidate vac-cines because they can sustain viral replication in relevant cell types and develop a robust immune response, but they do not develop overt disease. However, NHP models are not suitable for early preclinical studies be-cause the cost of using these animals is high. In contrast, mouse models that are established mainly by using wild-type and immunodeficient mice can be more economical for preclinical evaluation of dengue vaccines. Overall, every model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or preclinical testing of antiviral drugs.
Full text:
1
Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Microbiology and Immunology
Year:
2017
Type:
Article