Optimization of Clarification Technology of Water-soluble Chitosan on Huang'e Gel Water Extract by Box-Behnken Response Surface Method / 中国药房
China Pharmacy
;
(12): 3987-3991, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-659148
ABSTRACT
OBJECTIVE:
To optimize the technology conditions of water-soluble chitosan on Huang'e gel water extract solu-tion.METHODS:
Using the comprehensive scores of transmittance ratio,impurity removal rate,naringin retention rate as indexes, Box-Behnken response surface method was used to optimize the amount of water-soluble chitosan,shocking time and temperature in clarifying technology,and verification test was conducted.RESULTS:
The clarification effect was the best when the volume ra-tio of TCM extract solution with proportion ≥1.3 to amount of 0.01 g/mL water-soluble chitosan was 2.2,shocking for 100 min at 70 ℃. In the verification test,the average transmittance ratio was 87.3%,impurity removal rate was 41.5%,and naringin reten-tion rate was 131.38%. The measured values of comprehensive scores were 97.35%,98.92% and 98.04%,showing relative error of -0.87%,0.73% and -0.16% with the predicted values(98.27%),respectively.CONCLUSIONS:
The method can effectively optimize the clarification technology parameters of water-soluble chitosan on Huang'e gel water extract solution.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
China Pharmacy
Year:
2017
Type:
Article
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