Effect of Serum High Sensitive C Reactive Protein Level on the Curative Effect of Azithromycin in Treatment of Mycoplasma Pneumonia in Children / 医学研究杂志

ABSTRACT

Objective To investigate the effect of serum high sensitive C reactive protein (hs-CRP) level on the curative effect of azithromycin in treatment of mycoplasma pneumonia in children.Methods The 68 cases of children with mycoplasma pneumonia in Maternal and Child Health Care Hospital of Chongzhou were selected as the research objects from June 2013 to June 2016.All the children were treated with 10mg/kg azithromycin daily.The clinical symptoms,chest X-ray changes and adverse reactions of children during treatment were observed and the level of hs-CRP was determined by latex immunoassay.Results The mean value of serum hs-CRP was (19.06 ± 3.01),and the median of serum hs-CRP was 12.92mg/L,which were higher than the normal upper limit value of 10mg/L.Children were divided into high hs-CRP group and low hs-CRP group by the median value of hs-CRP.There were no significant differences in the age,sex,course of disease and body temperature between the two groups (P ＞ 0.05).The overall effective rate of low hs-C RP group was 94.12％,which was significantly higher than that of high hs-C RP group at 76.47％ (x2 =4.221,P =0.040).The duration of cough,wheezing and lesion absorption time in high hs-CRP group were longer than those in the low hs-CRP group (P ＜0.05).But no significant difference was observed in time of fever,hospitalization time,the incidence of adverse reactions between two groups (P ＞0.05).Conclusion hs-CRP plays an important role in children's mycoplasma pneumonia,and the clinical effect of azithromycin is much better on the patients with low level of hs-CRP.