Study on correlation between levels of hs-CRP, IL-6 and MMP-9 with cerebral microbleeding / 重庆医学

ABSTRACT

Objective To discuss the correlation between levels of hs-CRP,IL-6 and MMP-9 with cerebral microbleeding (CMB).Methods A total of 201 of non-acute ischemic cerebrovascular were collected and performed heal MRI+ susceptibility-weighted imaging(SWI).The patients were divided into the CMB group(49 cases) and non-CMB group(152 cases) according to the SWI examination results.The clinical data were recorded in the two groups.The levels of inflammatory mediators high-sensitivity C-reactive protein (hs-CRP),interleukin-6 (IL-6) and matrix metalloproteinase-9(MMP-9) were tested.The Logistic regression analysis was used to analyze the relation between the levels of hs-CRP,IL-6 and MMP-9 with cerebral microbleeding.Results The levels of inflammatory mediators hs-CRP,IL-6 and MMP-9 in the CMB group were significantly higher than those in the non-CMB group (P＜0.05).The logisticMultivariate logistic regression analysis showed that the levels of hs-CRP,IL-6 and MMP-9[OR value(95％CI)1.745(1.342-2.270),1.223(1.018-1.533),1.284(1.082-1.423),P＜0.05)] were the risk factors of CMB after adjusting the influence of age,sex and traditional risk factors.Conclusion The levels of inflammatory mediators hs-CRP,IL-6 and MMP-9 are closely associated with CMB,which participate in CMB occurrence.