Clinical significance of the expression of VEGF and bFGF in the mucosa of hepatogenic ulcer / 国际检验医学杂志

ABSTRACT

Objective To investigate the expression of vascular endothelial growth factor(VEGF) and basic fibroblast growth factor(bFGF) in gastric mucosa of patients with hepatogenic ulcer,and to analysis the relationship between them and the incidence of complications and disease progression in patients.Methods During July 2014 to May 2016,133 cases of patients with hepatocir rhosis and portal hypertension associated with gastric or duodenal ulcer were selected as study object.Marginal tissue of ulcer were collected,and normal mucosa tissue were collected as control group.Reverse transcription-polymerase chain reaction(RT-PCR) detect the expression of VEGF mRNA and bFGF mRNA in 133 cases of normal gastric mucosa and 133 cases of marginal tissue of ulcer,including 52 cases of gastric ulcer activity period(GA),45 cases of gastric ulcer healing period(GH) and 36 cases of gastric ulcer scar period(GS).Spearman correlation coefficient analysis the correlation between the expression of VEGF mRNA and bFGF mRNA and complication rate.Results The expression of VEGF mRNA and bFGF mRNA in ulcer marginal tissues was significantly higher than that in normal mucosa tissues,the difference was statistically significant(P＜0.05).The expression of VEGF mRNA in GH and GS of patients was significantly higher than that in GA patients,the difference was statistically significant (P＜0.05),the expression of bFGF mRNA in GS of patients was significantly higher than that of GA patients,the difference was statistically significant(P＜0.05).Spearman correlation analysis showed VEGF mRNA and bFGF mRNA was negatively correlated with incidence rate of ulcer complications (rs=-0.672,-0.508,P＜0.05).Conclusion bFGF mRNA and VEGF mRNA may play an important role in the repair of hepatogenic ulcer.It is a potential clinical marker.