Plasma level and activity of endotoxin in patients with ischemic stroke / 心血管康复医学杂志

ABSTRACT

Objective:To explore plasma level and activity of endotoxin (LPS)in patients with ischemic stroke (IS). Methods:A total of 80 IS inpatients were regarded as stroke group,and another 50 healthy subjects were treated as healthy control group.Plasma levels of LPS,LPS binding protein (LBP)and sCD14 were measured and compared between healthy control group and IS group on 1d and 3d after stroke.Results:Compared with healthy control group,there were significant rise in plasma levels of LPS,LBP and sCD14 in stroke group on 1d and 3d,P <0.01 all;compared with 1d after stroke,there were significant rise in plasma levels of LPS [(0.29 ±0.07)U/ml vs. (0.38±0.05)U/ml],LBP [(22.13±2.75)μg/ml vs.(27.16±3.75)μg/ml]and sCD14 [(1251.11±179.79)ng/ml vs.(1472.29±158.18)ng/ml]in stroke group on 3d after stroke,P =0.001 all.Conclusion:Plasma level and activity of endotoxin significantly rise in patients with ischemic stroke.It helps clinical physicians to diagnose ische-mic stroke by measuring plasma level and activity of endotoxin.