IL-31 and its soluble receptor expression in serum of patients with rheumatoid arthritis / 实用医学杂志

ABSTRACT

Objective Through testing levels of serum IL-31 and its soluble form of oncostatin M receptor (sOSMR)in patients with rheumatoid arthritis(RA)in disease activity and remission ,to analyze the relationship between their levels and disease activity ,and further explore the pathogenesis of RA and treatment to provide new ideas. Method 60 patients with RA were selected ,and 23 healthy controls were selected as controls. The serum levels of IL-31 and sOSMR in the 2 groups were detected by ELISA. Results Firstly,The levels of IL-31 in se-rum of RA patients were higher than those of control(P < 0.05). The levels of serum IL-31 in RA moderate and high activity group were higher than those in the low activity group and remission group(all P<0.05). There was no statistical difference between the level of serum sOSMR in RA and control(P>0.05),and the levels of serum sOSMR in RA activity groups and remission group were no statistical difference(P > 0.05). (2)The IL-31 were positively correlated with RF,CDAI,ESR and CRP levels(all P<0.05). Conclusion IL-31 may be involved in the pathological and development process of RA and related to disease activity ,which can be an indicator of RA disease activity assessment.