Study on the relationship between serum uric acid level and long-term prognosis in patients with neurologically asymptomatic carotid atherosclerosis / 中国综合临床

ABSTRACT

Objective To investigate the relationship between serum uric acid levels and long-term prognosis in patients with neurologically asymptomatic carotid atherosclerotic.Methods Six hundred and thirty-seven cases of carotid atherosclerosis treated in Wulanchabu Central Hospital from January 2013 to January 2017 were enrolled in the study.The clinical data of the patients were collected and the patients were divided into four groups according to the serum uric acid level.Kaplan-Meier method was used to calculate the survival rate of all deaths and cardiovascular diseases in each group,and the survival curve was drawn.Log-rank test was applied to compare the survival curve.Multivariate Cox proportional hazards model was used to assess the risk of serum uric acid levels in the prognosis of patients.Results The differences of hypertension, smoking history, hyperlipidemia,serum uric acid(SUA)and serum homocysteine were statistically significant among the four groups(P<0.05).There were significant differences in all-cause death(P=0.000)and cardiovascular-cause death(P=0.000)among the four groups.Cox regression analysis showed that serum acid was an independent risk factor of all-cause mortality(RR=1.262,95%CI1.084-2.119,P=0.025)and cardiovascular-cause mortality in patients with neurologically asymptomatic carotid atherosclerosis(RR=1.364,95%CI1.063-1.750,P=0.013).Conclusion Elevated serum uric acid level is an independent risk factor for patients with neurologically asymptomatic carotid atherosclerosis,which can increase the rate of all-cause mortality and mortality of cardiovascular disease,and has a significant impact on long-term prognosis.