The relationship between serum vitamin D and diabetic retinopathy in patients with type 2 diabetes mellitus / 复旦学报（医学版）

ABSTRACT

Objective To investigate the relationship between diabetic retinopathy(DR) and serum vitamin D in patients with type 2 diabetes mellitus (T2DM).Methods A total of 310 patients with T2DM both managed in the bio-bank and the diabetes management system of Center for Disease Control and Prevention of Minhang District during Feb.,2012 to Dec.,2014 were selected.Then 205 patients were divided into non diabetic retinopathy group (NDR) and 105 patients into DR group according to the fundus examinations.The patients' demographical information,medical history and laboratory essays were collected,serum 25 (OH)D levels were detected.Results Single factor analysis indicated that,compared with NDR group,25(OH)D level of DR group decreased(t =3.465,P＜0.001),prevalence of 25(OH)D deficiency rose (x2 =5.313,P =0.021),however,prevalence of 25 (OH) D insufficiency showed no statistical significance (x2 =0.990,P =0.320).Binary Logistic regression analyses showed the inverse correlation between 25 (OH)D level and DR (OR =0.954,95％CI0.926-0.983,P =0.002),in addition,the risk for DR in T2DM patients who were deficient in 25 (OH)D was 2.17 times than those who were not (OR =2.171,95％ CI1.047-4.500,P =0.037),after adjusting for a number of variables (demographics,medical history,fasting plasma glucose,postprandial blood glucose,triglyceride and uric acid).Conclusions Serum 25 (OH)D level was negatively related with DR in patients with T2DM.25 (OH)D deficiency might be relevant to the risk of type 2 diabetic retinopathy.