Significance of laparoscopy combined with MTX and mifepristone in the treatment of uterine scar pregnancy / 中国生化药物杂志

ABSTRACT

Objective To investigate the significance of laparoscopic hysterectomy combined with MTX and mifepristone in the treatment of uterine scar pregnancy. Methods 86 patients with uterine scar pregnancy from July 2015 to May 2017 in our hospital were selected as the subjects, were randomly divided into control group and experimental group, each group of 43 cases. The control group was treated with MTX and mifepristone, intramuscular injection of 50 mg/m2 methotrexate, mifepristone orally, 3 times a day. The patients in the experimental group received laparoscopic monitoring, combined with MTX and mifepristone treatment. The hospitalization time, cure rate and vaginal bleeding time of the experimental group and the control group were compared and analyzed. Results The success rate of the experimental group was 100.00%, which was significantly higher than that of the control group (72.42%), and the difference was statistically significant (P<0.05). The vaginal bleeding time in the experimental group was (20.87±6.54) days, significantly shorter than the control group, and the number of days was (34.20±10.89) days, with statistical difference (P<0.05). In the experimental group, the time required for the decrease of beta -HCG to normal was (26.90±9.21), and the time required for the decrease of beta-HCG to normal in the control group was (45.66±10.29), with statistical difference (P<0.05). Conclusion Laparoscopic monitoring uterine aspiration combined with Methotrexate and mifepristone in the treatment of uterine scar pregnancy ideal clinical curative effect, can significantly improve patients' clinical symptoms, high success rate, and faster recovery, high safety.