Progress in the study of the formation and function characteristics of stress granules and its correlation with diseases / 基础医学与临床

ABSTRACT

When eukaryotic cells face various environment stimulation,eukaryotic cells form some dense granules in hyalomitome,that are stress granules(SGs).They have antioxidant and inhibit apoptosis. Interaction between mRNA-binding proteins promotes stress granule formation. Assembly and disassembly of stress granules are modulated by va-rious post-translational modifications as well as numerous ATP-dependent RNP or protein remodeling complexes.Stress granules have the ability of liquidity,and energy input is required to maintain their dynamic state.Stress granule for-mation can regulate the process of stress reaction,virus infection and the signal transduction.The formation of constant and the abnormal stress granules result in neurodegenerative diseases and certain types of cancer.