Updates on OGG1 gene / 国际儿科学杂志

ABSTRACT

OGG1 gene is widely expressed in eukaryotic cells as a housekeeping gene,which can identi-fy 8-oxoG,oxidative damage product,and remove it via the base excision repair pathway to repair DNA and pro-tect it from mutation. Increasing attention is paid to investigate the OGG1 gene,which is found to play an impor-tant role in tumorigenesis,aging,degenetative diseases,cardiomyopathy,and allergic diseases. Insight of the ex-pression of OGG1 and its regulatory mechanism can bring us a new way to treat these diseases.