Specificity, sensitivity and significance analysis of coagulation and D-dimer in the early diagnosis of hypertension in pregnancy / 中国生化药物杂志

ABSTRACT

Objective To investigate the specificity and sensitivity of coagulation four and D-dimer in early diagnosis of hypertension in pregnancy and its clinical significance. Methods 120 cases of pregnant women with pregnancy induced hypertension in department of Laboratory, the third affiliated hospital of Jinzhou medical university from February to December in 2016, were enrolled in the observation group. According to their different conditions of disease, including 50 cases of pregnancy-induced hypertension, 40 cases of mild preeclampsia, 30 cases of severe preeclampsia. 30 cases of normal pregnant women were selected as the control group. The coagulation and the D-dimer of the pregnancy-induced hypertension group and the control group were detected. Results The D-dimer (D-D) and fibrinogen (FIB) in the observation group were higher than those in the control group, the prothrombin time (PT), the activated partial thromboplastin time (APTT) and the thrombin time (TT) were shorter than the control group, the difference was statistically significant (P<0.05). The levels of PT, APTT and TT in severe preeclampsia group were lower than those in the pregnancy-induced hypertension group, D-D and FIB were higher than those in pregnancy-induced hypertension group, and severe preeclampsia was lower than that in mild preeclampsia group. D-D, FIB were higher than mild preeclampsia group, APTT in the mild preeclampsia group lower than the pregnancy-induced hypertension group, DD, FIB higher than the pregnancy-induced hypertension group, the difference was statistically significant (P<0.05). Specificity and sensitivity of coagulation and D-dimer were higher than coagulation four, D-D dimer detection. Conclusion Coagulation and D-dimer are great value in the early diagnosis of hypertension and the severity of pregnancy. Joint detection could improve the specificity and sensitivity of diagnosis.