Tibolone combined with alendronate on curative effect of osteoporosis of women in perimenopausal and postmenopausal women / 中国生化药物杂志

ABSTRACT

Objective To study the analysis of tibolone combined with alendronate on curative effect of osteoporosis of women in perimenopausal and postmenopausal women. Methods 126 cases of perimenopausal and postmenopausal women with osteoporosis were selected from April 2015 to October 2016 in our hospital. The subjects were randomly divided into the control group and the experimental group, with 63 patients in each group. The control group were treated with oral compound amino acid chelated calcium treatment, the patients in the experimental group of tibolone combined with alendronate sodium. The treatment time of the experimental group and the control group was in December. The therapeutic effects of the experimental group and the control group were compared and analyzed. Results After the corresponding treatment, 63 patients in the experimental group, 16 patients were invalid, and 47 patients were effective. Of the 63 patients in the control group, 58 patients were ineffective, and 5 patients were treated effectively. The effective rate of treatment in the experimental group (92.1%) was significantly higher than that in the control group (74.6%), with statistical difference (P<0.05). In the experimental group, 4 patients had side effects, and 3 cases in the control group had side effects. There was no significant difference in the incidence of adverse reactions between the two groups, and there was no statistical difference. Conclusion Tibolone combined with alendronate sodium in the treatment of the clinical effect of women with osteoporosis in perimenopausal and postmenopausal women, high treatment efficiency, high safety, has clinical significance.