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Correction of matrix effect in determination of heavy metal elements in iron dextran by icp-oes internal standard method / 药物评价研究
Drug Evaluation Research ; (6): 1098-1102, 2017.
Article in Chinese | WPRIM | ID: wpr-659978
ABSTRACT
Objective To establish a method for the determination of 8 heavy metal elements of Pb,Cd,As,Hg,Co,V,Se,Mo in iron dextran by inductively coupled plasma optical emission spectrometry (ICP-OES).Method Through selection of detection wavelengths,optimization of instrument parameters,verification of matrix effect interference and investigation of internal standard for correction of matrix effect interference,the 8 heavy metal elements were analyzed by ICP-OES.Results The recovery rate of the detected elements were increased from 83%-90% to 94%-100%,after correction of matrix effect interference by internal standard method.The accuracy of the method were good.The spiked recoveries of the detected elements were from 94.3% to 101.5%.The precision of the method were good (RSD < 3.5%,n =6).The linearities of the detected elements were good,and the correlation coefficients were all greater than 0.999.The detection limits were from 0.22 to 8.54 ng/mL.The quantization limits were from 0.68 to 25.73 ng/mL.Conclusion The established method was accurate,sensitivity,rapid and reliable,which can be applied to the determination of contents of 8 heavy metal elements in iron dextran.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Drug Evaluation Research Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Drug Evaluation Research Year: 2017 Type: Article