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Effect of mB7 H4-Ig fusion protein on mouse psoriasis-like lesions induced by imi-quimod / 中国免疫学杂志
Chinese Journal of Immunology ; (12): 1509-1513,1519, 2017.
Article in Chinese | WPRIM | ID: wpr-660054
ABSTRACT

Objective:

To explore the effects of mB7H4-Ig fusion protein on mouse psoriasis-like lesions induced by imiquimod (IMQ) .

Methods:

The level of mB7H4-Ig fusion protein was detected by ELISA after hydrodynamic injection of recombinant plasmids. The therapeutic groups were injected with mB7H4-Ig plasmids and control groups were injected with Flag-Ig plasmids following IMQ treatment. 5 days after treatment,the skin lesions were determined by hematoxylin-eosin staining and the percentage of immune cells in murine peripheral blood cells was measured by flow cytometric analysis.

Results:

The expression of mB7H4-Ig fusion protein was detected in mouse sera after hydrodynamic injection. Compared with control groups,mB7H4-Ig groups were alleviated,with decreased epidermal inflammation and lower PASI scores. The percentage of neutrophils in peripheral blood was reduced significantly in mB7H4-Ig groups,but the percentage of CD4+T cell was increased.

Conclusion:

mB7H4-Ig fusion protein improved imiquimod induced psoriasis-like lesions by inhibiting the inflammatory response,indicating the potential therapeutic strategy of B7H4-Ig fusion in psoriasis.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Immunology Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Immunology Year: 2017 Type: Article