Relationship Between Neutrophil to Lymphocyte Ratio and Contrast-induced Nephropathy in Patients With Percutaneous Coronary Intervention / 中国循环杂志

ABSTRACT

Objective:To investigate the relationship between neutrophil to lymphocyte ratio (NLR) and contrast-induced nephropathy (CIN) in patients with percutaneous coronary intervention (PCI).Methods:A total of 176 patients received PCI in our hospital from 2015-05 to 2016-12 were enrolled.Blood levels of white blood cells (WBC),neutrophils (N),lymphocytes (L);serum creatinine (SCr),blood urea nitrogen (BUN),uric acid (UA),cystatin C (CysC) were examined within 24 h of admission and NLR was calculated.According to NLR,the patients were divided into 3 groupsLow NLR group,NLR＜1.60,n=58,Moderate NLR group,1.60≤NLR≤2.36,n=62 and High NLR group,NLR＞2.36,n=56.SCr and CysC were re-examined at 48 h and 72 h after PCI.Pearson analysis was conducted for correlation study and Logistic regression analysis was used to identify whether NLR was the risk factor for CIN occurrence.Results:Compared with baseline condition,SCr and CysC were increased in all 3 groups,all P＜0.05.Pearson analysis indicated that NLR was positively related to SCr and CysC elevation (r=0.785 and r=0.764),both P＜0.05;Logistic regression analysis presented that NLR was an independent risk factor for CIN occurrence.Conclusion:NLR was positively related to contrast induced kidney injury,it was the risk factor for CIN occurrence in PCI patients.