The clinical outcome of renal transplantation with a poor HLA matched living kidney donors / 대한내과학회지
Korean Journal of Medicine
;
: 402-409, 2005.
Article
in Korean
| WPRIM
| ID: wpr-66022
ABSTRACT
BACKGROUND:
Poor HLA matched donors may become an additional organ source for renal transplantation. This study is conducted to predict the clinical outcomes of renal transplantation in a poor HLA matched group (0 or 1 or 2 HLA matching) by comparing them with those of HLA haploidentical group.METHODS:
This study compared a poor HLA matched group (N=89) with HLA haploidentical group (N=79) to analyze differences between two groups in graft survival, incidence of acute rejection, cause of graft failure, posttransplant serum creatinine at 1, 2, 3, 5 years. Total 168 cases, appeared in the medical records for more than six months in Bong-Saeng Hospital, from December, 1984 to March, 2004 were traced and identified as relevant cases for this study.RESULTS:
Allograft survival rate at 1, 3, 5, 10 years for poor HLA matched group and HLA haploidentical group were 100%, 98.6%, 95.4%, 72.5% and 100%, 100%, 96.1%, 86.2% (p=not significant) respectively. Acute rejection developed in 25.8% of poor HLA matched group versus 18.9% of HLA haploidentical group (p=not significant). The most common causes of graft failure in both groups were chronic rejection.CONCLUSIONS:
It should be actively encouraged to consider renal transplantation in a poor HLA matched group as the results of this study support that the clinical outcomes of renal transplantation in a poor HLA matched group are equivalent to those of HLA haploidentical group.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Research Design
/
Tissue Donors
/
Medical Records
/
Incidence
/
Survival Rate
/
Kidney Transplantation
/
Transplants
/
Creatinine
/
Allografts
/
Graft Survival
Type of study:
Incidence study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2005
Type:
Article
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