Expression in the serum and the instruction value of interleukin-13 ,interleukin-18 and tumor necrosis factor-α in children with mycoplasma pneumoniae pneumonia / 国际检验医学杂志

ABSTRACT

Objective To observe the different expression of interleukin(IL)-13 ,IL-18 and tumor necrosis factor(TNF)αin my-coplasma pneumoniae pneumoni achildren with different clinical symptoms ,and explore the value of serum IL-13 ,IL-18 and TNF-αon clinical diagnosis ,judgement of disease ,clinical treatment of mycoplasma pneumoniae pneumonia in children .Methods A total of 120 children with mycoplasma pneumoniae pneumonia cases(observation group) and 60 cases of healthy children(control group) during June to October in 2016 in our hospital were recruited as objects in this research .The levels of serum IL-13 ,IL-18 and TNF-αwere compared between patients in acute phase and convalescence ,between patients with mild illness and severe illness ,between patients with wheezing and without wheezing ,between patients with pulmonary fibrosis and without pulmonary fibrosis ,between children with mycoplasma pneumoniae pneumonia and healthy children .Results The expression of serum IL-13 ,IL-18 and TNF-αin all children with mycoplasma pneumoniae pneumonia were significantly higher than those of healthy children (P<0 .05) .Acute phase and convalescence ,severe illness with mild condition ,with breathing and are not associated with breathing ,changes in sample with pulmonary fibrosis and pulmonary fibrosis change of mycoplasma pneumoniae pneumonia in children with serum IL-13 ,IL-18 and the expression level of TNF-αcomparative has significant difference ,and the former is higher than the latter(P<0 .05) .Conclu-sion Serum IL-13 ,IL-18 and TNF-αparticipate in the condition of mycoplasma pneumoniae pneumonia development process ,they are important reference indexes of clinical diagnosis ,illness conditions determination and treatment of mycoplasma pneumoniae pneumonia .