Clinical effects of somatostatin combined with Qingyi decoction in the treatment of acute pancreatitis / 中国基层医药

ABSTRACT

Objective To investigate the clinical effects of somatostatin combined with Qingyi decoction in the treatment of acute pancreatitis. Methods 120 patients with acute pancreatitis were chosen as observation subjects,and they were randomly divided into control group and observation group according to the digital table. The control group was treated with somatostatin,the observation group was treated with Qingyi decoction on the basis of control group. The clinical effects,improvements of clinical indicators and symptom,adverse reaction between the two groups were compared. Results The total effective rate of the observation group(100. 00%) was higher than that of the control group(90. 00%),the difference was statistically significant (χ2 =6. 316,P<0. 05). Before treatment, there were no statistically significant differences between the two groups in clinical indicators ( t =0. 047,0. 069, 0. 040,0. 279,0. 064,0. 101,0. 333,all P>0. 05). After treatment,the albumin of the observation group was higher than that of the control group,white blood cell count,APACHEⅡ score,C reactive protein,serum amylase,aspartate aminotransferase and lactate dehydrogenase were lower than those in the control group, the differences were statistically significant (t=14. 822,11. 654,15. 849,20. 000,10. 509,15. 213,15. 191,all P <0. 05). The blood amylase,abdominal pain relief,recovery of gastrointestinal function,urinary amylase,abdominal distension,ventilator weaning,abdominal tenderness disappeared and so on symptom improvement time of the observation group were earlier than those of control group,the hospital stay was shorter than that of the control group,the differences were statistically significant (t=10. 479,15. 855,8. 705,13. 064,8. 965,11. 783,11. 347,17. 069,7. 058,all P<0. 05). The incidence rate of adverse reactions in the control group was higher than that in the observation group(11. 67% vs. 1. 67%),the difference was statistically significant (χ2 = 4. 821, P < 0. 05 ). Conclusion Qingyi decoction combined with somatostatin can effectively improve the clinical symptom of acute pancreatitis,and with good clinical effects and safety.