Effect of atomization inhalation of ambroxol hydrochloride combined with erythromycin on high sensitivity C reactive protein, myocardial enzyme level in neonatal pneumonia patients / 中国基层医药

ABSTRACT

Objective To investigate the effect of ambroxol atomization inhalation combined with erythromycin on neonatal pneumonia patients and its influence on high sensitivity C reactive protein( hs-CRP) ,myocardial enzyme level. Methods 100 cases of neonatal pneumonia were selected and they were randomly divided into observation group and control group according to the digital table,50 cases in each group. The control group was treated with erythromycin 30mg/kg, 1 time/d. The observation group was given ambroxol ultrasonic nebulizer inhalation, 15 minutes per time,3 times daily,on the basis of the treatment of the control group. The patients were treated for 4 consecutive weeks. The clinical symptoms disappeared time, hs -CRP level, CK -MB level and clinical efficacy were detected and compared. Results Compared with before treatment, the hs - CRP and CK - MB levels were decreased after treatment. Compared with the control group,the hs - CRP[(7. 25 ± 2. 11) mg/L vs. (12. 21 ± 3. 76)mg/L] and CK-MB[(21. 31 ± 4. 42) U/L vs. (27. 12 ± 3. 17) U/L] levels in the observation group were lower(t=8. 134,7. 553,all P<0. 05),the clinical symptoms disappeared in a relatively shorter time(t= 6. 520, 11. 824,19. 473,all P <0. 05),the clinical curative effect was better. Conclusion Ambroxol aerosol inhalation combined with erythromycin can reduce hs-CRP,CK-MB levels in neonatal pneumonia patients,and the clinical symptoms of the patients disappeared in a relatively short time, the clinical curative effect is better, has guiding significance in clinic.