Gene expression of liver nuclear receptor LRH-1 and scavenger receptor class B type I gene in cholesterol gallstone mice / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery
;
(4): 511-514, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-660397
ABSTRACT
Objective:
To investigate the expressions of liver receptor homolog 1 (LRH-1) and scavenger receptor B type Ⅰ (SRBI) gene in cholesterol gallstone (CGS) mice.Methods:
Forty C57BL/6 mice,20 with cholesterol gallstone (GS)and 20 controls without gallstones (GSF) were enrolled in this study.mRNA and protein expression of LRH-1 and SRBI genes were determined by RT-PCR and Western blot.Results:
Gallbladder walls of GS mice were thicker with increased stromal granulocyte infiltration.The expression levels of LRH-1 genes were significantly higher in GS mice than in controls(P<0.01).The expression levels of SRBI genes were also significantly higher in GS mice than in controls(P<0.01).Conclusion:
The increased expression of LRH-1 and SRBI gene may be related to GS disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Current Advances in General Surgery
Year:
2017
Type:
Article
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